Cellceutix Plans for Entry into Diabetic Foot Wound and Ulcer Market

Cellceutix Study Shows Brilacdin to Expedite Healing in Animal Model of Diabetic Foot Wounds

BEVERLY, MA–(Marketwired-–May 19,2014)- Cellceutix Corporation (OTCQB: CTIX) (the “Company”), a clinical stage biopharmaceutical company developing innovative therapies in oncology, dermatology, and antibiotic applications, is pleased to report that its lead antibiotic, Brilacidin™, demonstrated visually convincing wound healing properties in a recently completed experiment in a diabetic rat model.

As a small molecule mimetic of human host defense proteins, brilacidin has demonstrated antibacterial and tissue healing properties on barrier surfaces, such as skin and mucous membranes. Results from the diabetic rat study are consistent with these properties.

In the study, diabetic rats with similar non-infected diabetic wounds were treated with Brilacidin for five days and compared to an untreated control. By visual inspection, the brilacidin-treated animals experienced a more rapid and complete reduction in the area of the wound. Additional experiments are now scheduled in infected diabetic wound models. Afterwards, the Company anticipates entering the necessary clinical trials.

“We already know that Brilacidin has strong anti-infective properties, so the trial was designed to validate our contention that the drug also expedites the healing process in wounds that are free of infection; a powerful one-two punch in the treatment of diabetic foot wounds, regardless of infection,” commented Dr. Krishna Menon, Chief Scientific Officer at Cellceutix. “Through the combination of our internal research and the ongoing Phase 2b clinical trial of Brilacidin for ABSSSI, we are rapidly growing a large body of evidence demonstrating the potential clinical benefits of Brilacidin across a broad spectrum of indications of great unmet medical need.  Last week, we moved one step closer to the initiation of a Phase 2 clinical trial of Brilacidin for oral mucositis through the receipt of the draft GLP toxicology report.  We expect the final report within the next few weeks, at which time we will add it to the Investigational New Drug application for submission to the U.S. Food and Drug Administration.”

Because of compromised peripheral nerves and blood vessels, diabetic foot wounds readily become a chronic condition and represent a leading cause of hospitalization and amputation for the approximately 26 million people living with diabetes in the United States.  Most of these wounds, at one time or another, get infected. According to the American Podiatric Medical Association, a chronic diabetic foot wound occurs in approximately 15 percent of people with diabetes.  Of those patients, up to 18 – 24 percent will require an amputation. Cellceutix believes the market size for an effective treatment is significantly larger than the ABSSSI market that alone is greater than a billion dollars in the U.S., thus the Company is targeting a potential multibillion-dollar worldwide market.